Scientific Research and Innovation Services (formally Contract Research and Development)

Department overview

Welcome to Scientific Research and Innovation Services at King’s College Hospital, where innovation drives excellence in clinical research. Our department plays a vital role in advancing medical knowledge, technology, and patient outcomes through the management of clinical trials and the specialist testing of research samples.

We provide a clinically validated, ISO 15189 accredited cytokine testing service that supports clinical teams across our partner NHS Trusts, private healthcare providers, and academic institutions. This unique national service underpins diagnostic innovation and research excellence.

At the core of our work is the expert delivery of clinical trial services, including contract setup and management, regulatory support, bespoke testing, service evaluations, new test validation, and the analysis of research samples. Every sample is managed with precision and care, ensuring high-quality, reliable results that contribute to groundbreaking clinical research.

Our experienced team of scientists and subject matter experts work collaboratively across disciplines and organisations, pushing the boundaries of medical science through innovation and integrity.

We are proud to be enabling the future of healthcare, one discovery at a time.

General documentation

Clinical Cytokine Service

Welcome to our UKAS-Accredited Cytokine Analysis Service

Our Cytokine Analysis Service is dedicated to delivering high-quality, reliable cytokine profiling for both research and clinical applications. UKAS-accredited and built on a foundation of precision, accuracy, and scientific integrity, our service ensures you receive dependable data to support both study outcomes and clinical decision making.

Utilising advanced technologies and fully validated methodologies, our experienced team provides comprehensive cytokine analysis tailored to your specific research or healthcare needs. Whether you're conducting basic research, running clinical trials, or evaluating therapeutic interventions, we are committed to supporting your work with expertise, responsiveness, and a focus on quality

What Are Cytokines, and Why Do They Matter?

Cytokines are small proteins produced by immune and other cells that serve as essential signalling molecules within the immune system. Acting as chemical messengers, they coordinate immune and inflammatory responses, enabling effective communication between cells.

Cytokines are vital for fighting infections, repairing tissue damage, and regulating immune system activity to maintain health and homeostasis. There are several classes of cytokines, including interleukins, interferons, tumour necrosis factors, growth factors, and chemokines—each playing a unique role in modulating the body's immune responses.

Routine Cytokine Panels – For Clinical Evaluation

We offer serum-only, validated routine cytokine panels for clinical evaluation. These panels are UKAS-accredited and conducted to the highest quality standards

Cytokine Panels                Cytokine Analytes                                                                            Turnaround Times

CY19                                   Interleukin-1β (IL-1β)                                                                        7 working days                                                                                                                                                             

                                             Interleukin-6 (IL-6)                                                                                                                                                                                                                                                                                

                                             Interleukin-8 (IL-8)                                                                                                                                                                                                                                                      

                                             Tissue necrosis factor-α (TNF-α)           

CY20                                    Interleukin-2 receptor alpha chain (IL-2ra)*                                  14 working days                                                                                                                                                                      

                                              Interleukin-10 (IL-10)                                                                                                                                                                                                                                                                       

                                              Interleukin-17 (IL-17)                                                                                                                                                                                                                                                                           

                                              Interferon-γ (INF-γ)

CY21                                    Interleukin-15 (IL-15)                                                                        14 working days                                                                                                                                                                   

                                             Granulocyte-macrophage colony-stimulating factor (GM-CSF)                                                                                                                                                                                        

                                             Monocyte chemoattractant protein-1 (MCP-1)                                                                                                                                                                                                                            

                                             Vascular endothelial growth factor (VEGF)

CY23                                    Interleukin-5 (IL-5)                                                                              14 working days                                                                                                                                                                

                                              Interleukin-13 (IL-13)

* IL-2ra is not to be confused with Interleukin-2 (IL-2), which has differing utility, both these markers should not be used interchangeably.

How to Request Our Cytokine Testing Service

To request testing:

• Click the Cytokine Information Form button below.
• Complete the form.
• Email the completed form to: synnovis.researchenquiries [at] synnovis.co.uk

 Custom Cytokine Panels – For Research Use Only

The Scientific Research & Innovation Laboratory also offers customised cytokine panels tailored for research use. These flexible panels can be designed to meet the specific objectives of your study and may include sample types outside our accredited scope.

Please note: All customised cytokine panels are batch-analysed once all study samples have been collected.

For more information or to discuss your research requirements, please contact us at: synnovis.researchenquiries [at] synnovis.co.uk

Research Studies & Clinical Trials

At Synnovis, we provide end-to-end support for clinical trials and research studies through our dedicated Scientific Research & Innovation (SR&I) Contracts Team. Whether supporting commercial or non-commercial research, our team ensures all contractual and regulatory obligations are met efficiently—enabling researchers to focus on delivering meaningful results.

Clinical trials and research must comply with stringent protocols and regulations, including MHRA, Good Clinical Practice (GCP), Human Tissue Authority (HTA), and require approvals through processes such as REC and IRAS. Our team works closely with clinical research leads to secure the necessary regulatory and governance approvals, ensuring smooth and compliant study initiation.

The SR&I Contracts Team supports research activity across all our partner Trusts including, Guy’s and St Thomas’ (GSTT), King’s College Hospital (KCH), Princess Royal University Hospital (PRUH), and Royal Brompton and Harefield (RBH-HH)—as well as with other NHS organisations, academic institutions, and private healthcare providers.

Our Services Include:

• Feasibility assessments.
• Costing and budget negotiations.
• Contract execution and management, including MTAs, NDAs, and amendments.
• Study setup and ongoing management

Our goal is to support the successful delivery of research that advances medical science and improves patient outcomes through expert, responsive, and collaborative service.

How to Request Pathology Costings

To begin, please complete the Research Information Form (RIF) by clicking the button below. Once completed, email the form to: synnovis.researchenquiries [at] synnovis.co.uk

Please also include the study protocol and lab manual (if available).Our SR&I Contracts Team will contact you to guide you through the next steps and provide ongoing support throughout the process.

 Bespoke Services

In addition to our wide scientific expertise and accredited testing repertoire, the SR&I Team offers bespoke biomarker analysis tailored to your specific research needs. We assist investigators with customised trial design, protocol refinement, method validation, project oversight, and kit evaluation.

We also manage:

• Manual sample processing.
• Data generation and secure entry in line with GCP
• Sample receipt logging and compliant storage at -20°C / -80°C in line with HTA regulations

For more detailed information, please refer to our User Guide and Test Repertoire in the General Documentation section.