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Purine Research Laboratory at Blackfriars Hub

Laboratory overview

Opening hours: Monday to Friday, 9am - 5:30pm

Our laboratory has been providing specialised diagnostic services for purine and pyrimidine disorders to the NHS since the early 1970s.

Research into these areas, as well as into pharmacogenetics and therapeutic drug monitoring, continues to be translated into the diagnostic service and clinical practice.

Key features:

Vertical T

We provide a comprehensive diagnostic service for:

  • Inherited disorders of purine and pyrimidine metabolism (metabolite screens on urine and plasma, enzyme assays and genetic testing).
  • Pharmacogenetics and therapeutic drug monitoring to personalise the therapy of drugs targeting purine and pyrimidine metabolic pathways (thiopurines, fluoropyrimidines and low dose methotrexate).
  • Departments and laboratories
  • Phlebotomy training
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Last updated on 30/01/2026
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view our tests
Tuesday, 30 August, 2016
A practical guide to thiopurine prescribing and monitoring in IBD
Ben Warner , Emma Johnston , Monica Arenas-Hernandez , , Peter Irving , Jeremy Sanderson
Friday, 19 December, 2014
A practical guide to the use of thiopurines in oral medicine.
Hullah EA , Blaker PA , , Escudier MP , Sanderson JD
Friday, 14 June, 2013
The Mechanism of Allopurinol Induced TPMT Inhibition
Up to 1/5 of patients with wildtype thiopurine-S-methyltransferase (TPMT) activity prescribed azathioprine (AZA) or mercaptopurine (MP) demonstrate a skewed drug metabolism in which MP is preferentially methylated to yield methylmercaptopurine (MeMP)
Blaker PA , Arenas-Hernandez M , Smith MA , Shobowale-Bakre EA , Fairbanks L , Irving PM , Sanderson JD , Marinaki AM
Tuesday, 4 June, 2013
Genetic markers associated with toxcity to fluoropyrimidine therapy
Fluoropyrimidine drugs are extensively used for the treatment of solid cancers.
Loganayagam A, , Arenas-Hernandez M , Corrigan A , L Fairbanks , Lewis CM , Harper P , Maisey N , Ross P , Sanderson JD , Marinaki AM
Tuesday, 30 April, 2013
The influence of gender and haemoglobin on TPMT activity
Pre-treatment measurement of red blood cell (RBC) thiopurine-S-methyltransferase (TPMT) activity is recommended to guide initial dosing of azathioprine (AZA) and mercaptopurine (MP).
P A Blaker , V C Kariyawasam , K V Patel , R M Goel , M G Ward , P M Irving , , J D Sanderson
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Erin Emmett
Principal Clinical Scientist
Monica Arenas-Hernandez
Principal Clinical Scientist

Purine Research Laboratory at Blackfriars Hub

020 4 591 0058
Reference Chemistry, 1st Floor Blackfriars Hub
41-43 Friars Bridge Court
Blackfriars Road
London
SE1 8NZ

Last updated: 30/01/2026

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Working with our NHS service partners to set the standard for the future of pathology

 

Gyu's and St Thomas'
King's College Hospital

 

Viapath is a founding member of The Association of Independent Pathology Providers (AIPP), which is a trade association representing innovative research-based diagnostic testing companies. 

Copyright 2014-2026 Synnovis Group LLP. Synnovis, the Synnovis logo and Nutris are registered trademarks of Synnovis Group LLP.

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What we do
  • Departments and laboratories
  • Phlebotomy training
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  • Swiftqueue
Our tests
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  • Test information
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